Catharanthus roseus (L.) Don. or commonly also known as Madagascar periwinkle (Fig. 1) is a plant that has quite extensive been studied. The studies have emphasized on the chemical content as it’s used for natural medicines. This plant has been known because of commercially valued for sheltering more than 130 bioactive Terpenoid Indole Alkaloids (TIAs). Two of them that have been widely used for several anticancer chemotherapies are vinblastine and vincristine – the leaf-derived bisindol alkaloids (Chung et al. 2011; Man et al. 2012; Verma et al. 2012).
Chung et al. (2011) states that one well-studied plant metabolite is terpenoid indole alkaloids (TIAs) a class of alkaloids. A commercial source of TIAs such as vinblastin and vincristine were extracted from stems and leaves of Catharanthus roseus are used for anticancer drugs (Chung, et al., 2011). Other alkaloids such as ajmalicine and serpentine can be used to treat hypertension.
The information of the wealth of the C. roseus plants today have already available regarding their biosynthesis from plant organelles and tissues (Ferreres at al. 2011) or even up to the enzymes and corresponding genes levels (Facchini 2001, 2006; Facchini and De Luca 2008; Ziegler and Facchini 2008; Oudin et al. 2007). Recent studies on C. roseus plant have been conducted on the effect of bacteria for the generation of that plant (Wang et al. 2012) and the use of nanoparticle of C. roseus leaves as antiplasmodial activities (Ponarulselvam, 2012).